THE ROLE OF NONHISTONE LACTYLATION IN DISEASE

The role of nonhistone lactylation in disease

In 2019, a novel biodegradable latex balloons post-translational modification termed lactylation was identified, which established a connection among lactate, transcriptional regulation and epigenetics.Lactate, which is traditionally viewed as a metabolic byproduct, is now recognized for its significant functional role, including modulating the tum

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The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions

Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors.Promyelocytic leukemia zinc-finger (Plzf, also known as Zbtb16) has been identified as a critical transcription factor influencing various signaling and differentiation pathways.Plzf plays a pivotal role in regulating

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